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  • 产品名称:兔抗Mapt (phosphoSer416)多克隆抗体

  • 产品型号:100ul
  • 产品厂商:通蔚生物
  • 产品价格:1800
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兔抗Mapt (phospho-Ser416)多克隆抗体 公司是一家集科研、开发、销售为一体的高科技企业,主要经营进出口化学试剂,ELISA试剂盒、生命科学科研产品、实验室设备、耗材等,为了更好的服务好每一位顾客,始终把产品品质和人力资源视为企业发展的原动力。
详情介绍:


中文名称:  兔抗Mapt (phospho-Ser416)多克隆抗体  

英文名称: Anti-Mapt (phospho-Ser416) rabbit polyclonal antibody

别      名: pTau; Mtapt; RNPTAU

相关类别: 一抗

储      存: 冷冻(-20℃) 避光

宿      主: Rabbit

抗      原: Mapt (phospho-Ser416)

反应种属: Human, Mouse, Rat

标 记 物: Unconjugate

克隆类型: rabbit polyclonal

技术规格

Background:

Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3).

Applications:

WB

Name of antibody:

Mapt (phospho-Ser416)

Immunogen:

Synthetic peptide of Rat Mapt (phospho-Ser416)

Full name:

microtubule-associated protein tau (phospho-Ser416)

Synonyms:

pTau; Mtapt; RNPTAU

SwissProt:

P19332

WB Predicted band size:

48 kDa; 62 kDa; 78 kDa

WB Positive control:

Rat brain, Rat hippocampus and Mouse brain tissue

WB Recommended dilution:

500-1000



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