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  • 产品名称:SETD2抗原(重组蛋白)

  • 产品型号:1mg
  • 产品厂商:通蔚生物
  • 产品价格:3580
  • 产品库存:35
  • 产品文档:
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详情介绍:

中文名称: SETD2抗原(重组蛋白)


英文名称: SETD2 Antigen (Recombinant Protein)

别     名:  HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP

储     存:  冷冻(-20℃)

相关类别: 抗原

概    述:

Fusion protein corresponding to C terminal 250 amino acids of human SETD2

技术规格


Full name:

SET domain containing 2

Synonyms:

HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP

Swissprot:

Q9BYW2

Gene Accession:

BC117162

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.





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