别 名： PVS; HVED; CD155; NECL5; TAGE4; Necl-5
概 述：
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Full name: |
poliovirus receptor |
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Synonyms: |
PVS; HVED; CD155; NECL5; TAGE4; Necl-5 |
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Swissprot: |
P15151 |
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Gene Accession: |
BC015542 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. |
