储 存： 冷冻（-20℃）
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Full name: |
phosphatidylinositol-4-phosphate 5-kinase, type I, beta |
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Synonyms: |
MSS4; STM7 |
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Swissprot: |
O14986 |
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Gene Accession: |
BC030587 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Phosphatidylinositol-4-phosphate-5-kinase (PIPK) synthesizes phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. The PIPK family is divided into type I, type II and type III . Each type of the PIPK family phosphorylate distinct substrates and they contain an activation loop, which determines their enzymatic specificity and subcellular targeting . The phosphatidylinositol-4-phosphate-5-kinase type I consists of three members, PIPK I ?, ∫, and ?, which are characterized by phosphorylating PI4P on the 5-hydroxyl . PIPK I ? (designated PIPK I ∫ in mouse) is expressed in brain tissue . PIPK I ∫, designated PIPK I a in mouse, is also called STM7. PIPK I ? has two variants produced by alternative splicing which are expressed in lung, brain, and kidneys. |
