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  • 产品名称：DAB2抗原（重组蛋白）

  • 产品型号：1mg
  • 产品厂商：通蔚生物
  • 产品价格：3580
  • 产品库存：35
  • 产品文档：
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简单介绍：
我司专业代理销售DAB2抗原（重组蛋白），质量保证，值得信赖，将以更上等的产品、更精湛的技术、更完善的服务、更饱满的热情服务于大家，如果你想了解更多关于抗体的详细信息，欢迎来电来函！
详情介绍：
中文名称： DAB2抗原（重组蛋白）

英文名称： DAB2 Antigen (Recombinant Protein)

别     名：  DOC2; DOC-2

储     存：  冷冻（-20℃）

相关类别： 抗原

概     述：

Fusion protein corresponding to a region derived from 209-447 amino acids of human DAB2

技术规格

Full name:

DAB adaptor protein 2

Synonyms:

DOC2; DOC-2

Swissprot:

P98082

Gene Accession:

BC003064

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.





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