别 名： LK4; hCERK; dA59H18.2; dA59H18.3
储 存： 冷冻（-20℃）
概 述：
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Full name: |
ceramide kinase |
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Synonyms: |
LK4; hCERK; dA59H18.2; dA59H18.3 |
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Swissprot: |
Q8TCT0 |
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Gene Accession: |
BC126940 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation. Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. |
