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  • 产品名称：RNF144B 抗原（重组蛋白）

  • 产品型号：100ug
  • 产品厂商：通蔚生物
  • 产品价格：800
  • 产品库存：35
  • 产品文档：
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简单介绍：
RNF144B 抗原（重组蛋白）为感谢各大科研机构长期以来对我发货单的支持，我司特在精品发布的同时开展一周促销活动，主要形式为送礼活动，低至9折起售，凡买及送的哦！好机会不错过！了解详细信息来电咨询哦！也可以通过在本站留言的，我们一定在半个工作内给您回复。
详情介绍：

中文名称： RNF144B 抗原（重组蛋白）

英文名称： RNF144B Antigen (Recombinant Protein)

别     名：  ring finger protein 144B; PIR2; IBRDC2; p53RFP; bA528A10.3

储     存：  冷冻（-20℃）

相关类别： 抗原

概     述

Fusion protein corresponding to N terminal 250 amino acids of human RNF144B

技术规格

Full name:

ring finger protein 144B

Synonyms:

PIR2; IBRDC2; p53RFP; bA528A10.3

Swissprot:

Q7Z419

Gene Accession:

BC063311

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.






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