概 述
| 
					 Full name:  | 
				
					 kelch-like ECH-associated protein 1  | 
			
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					 Synonyms:  | 
				
					 INrf2; KLHL19  | 
			
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					 Swissprot:  | 
				
					 Q14145  | 
			
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					 Gene Accession:  | 
				
					 BC002417  | 
			
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					 Purity:  | 
				
					 >85%, as determined by Coomassie blue stained SDS-PAGE  | 
			
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					 Expression system:  | 
				
					 Escherichia coli  | 
			
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					 Tags:  | 
				
					 His tag C-Terminus, GST tag N-Terminus  | 
			
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					 Background:  | 
				
					 This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.  | 
			
