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  • 产品名称：NAVA 抗原（重组蛋白）

  • 产品型号：1mg
  • 产品厂商：通蔚生物
  • 产品价格：3580
  • 产品库存：35
  • 产品文档：
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简单介绍：
NAVA 抗原（重组蛋白）一直视质量控制为企业的生命，追求企业竞争力的不断提升，始终秉承信誉为生存之本的宗旨，以过硬的质量和优良的服务来维护和拓展市场，*大限度的满足客户的需求，与客户共赢，是我们的发展目标，愿与您精诚合作，共创美好的未来。
详情介绍：



中文名称： NAVA 抗原（重组蛋白）

英文名称： INAVA Antigen (Recombinant Protein)

别     名： i nnate immunity activator; C1orf106

储     存：  冷冻（-20℃）  

相关类别： 抗原

概     述

Fusion protein corresponding to a region derived from 464-663 amino acids of human INAVA

技术规格

Full name:

innate immunity activator

Synonyms:

C1orf106

Swissprot:

Q3KP66

Gene Accession:

BC106877

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).






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