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  • 产品名称:IDE抗原(重组蛋白)

  • 产品型号:1mg
  • 产品厂商:通蔚生物
  • 产品价格:3580
  • 产品库存:35
  • 产品文档:
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简单介绍:
IDE抗原(重组蛋白)一直视质量控制为企业的生命,追求企业竞争力的不断提升,始终秉承信誉为生存之本的宗旨,以过硬的质量和优良的服务来维护和拓展市场,*大限度的满足客户的需求,与客户共赢,是我们的发展目标,愿与您精诚合作,共创美好的未来。
详情介绍:



中文名称: IDE抗原(重组蛋白)

英文名称: IDE Antigen (Recombinant Protein)

别     名:  INSULYSIN

储     存:  冷冻(-20℃)

相关类别: 抗原

概     述

Fusion protein corresponding to a C terminal 300 amino acids of human IDE

技术规格

Full name:

insulin-degrading enzyme

Synonyms:

INSULYSIN

Swissprot:

P14735

Gene Accession:

BC096336

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.







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