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  • 产品名称：DFFA抗原（重组蛋白）

  • 产品型号：1mg
  • 产品厂商：通蔚生物
  • 产品价格：3580
  • 产品库存：35
  • 产品文档：
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我司的DFFA抗原（重组蛋白）受到了广大科研单位的一致肯定和认同，产品有保证，价格公道，倾力为国内外科研院校实验室提供*上等的产品。若有需要，我司将竭诚为您服务，欢迎广大用户来电来涵购买！当天生产，发货及时，国内包邮。
详情介绍：


中文名称： DFFA抗原（重组蛋白）

英文名称： DFFA Antigen (Recombinant Protein)

别     名：  DFF1; ICAD; DFF-45

储     存：  冷冻（-20℃）

相关类别： 抗原

概     述

Fusion protein corresponding to N terminal 269 amino acids of human DFFA

技术规格

Full name:

DNA fragmentation factor, 45kDa, alpha polypeptide

Synonyms:

DFF1; ICAD; DFF-45

Swissprot:

O00273

Gene Accession:

BC007721

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.





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