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  • 产品名称：BRCA1抗原（重组蛋白）

  • 产品型号：1mg
  • 产品厂商：通蔚生物
  • 产品价格：3580
  • 产品库存：35
  • 产品文档：
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简单介绍：
BRCA1抗原（重组蛋白）打造了一支训练有素的技术团队，为抗体产品质量提供了强有力的保障，一直致力于研发生产高质量的科研试剂，为生命科学提供**的蛋白检测相关产品，先进的实验设备，强大的技术力量，诚信的服务态度是您实验成果的保障！
详情介绍：


中文名称： BRCA1抗原（重组蛋白）

英文名称： BRCA1 Antigen (Recombinant Protein)

储     存：  冷冻（-20℃）

相关类别： 抗原

概     述

Fusion protein corresponding to C terminal 300 amino acids of human BRCA1

技术规格

Full name:

breast cancer 1, early onset

Synonyms:

IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53

Swissprot:

P38398

Gene Accession:

BC072418

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.





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