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  • 产品名称：WWTR1 抗原（重组蛋白）

  • 产品型号：1mg
  • 产品厂商：通蔚生物
  • 产品价格：3580
  • 产品库存：35
  • 产品文档：
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简单介绍：
WWTR1 抗原（重组蛋白）研发生产的产品‍‍‍‍在免疫、分子生物等多个领域得到广泛应用，以过硬的质量、合理的价格、上等的服务为不同客户提供*专业的实验室配备解决方案与售后服务，受到了市场的认可与欢迎，赢得了良好的信誉和口碑。
详情介绍：

中文名称： WWTR1 抗原（重组蛋白）

英文名称： WWTR1 Antigen (Recombinant Protein)

别     名：  WW domain containing transcription regulator 1; TAZ

储     存：  冷冻（-20℃）

相关类别： 抗原

概     述

Fusion protein corresponding to a region derived from 201-400 amino acids of human WWTR1

技术规格

Full name:

WW domain containing transcription regulator 1

Synonyms:

TAZ

Swissprot:

Q9GZV5

Gene Accession:

BC014052

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.




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