储 存： 冷冻（-20℃）
相关类别： 抗原
概 述
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Full name: |
ORMDL sphingolipid biosynthesis regulator 3 |
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Swissprot: |
Q8N138 |
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Gene Accession: |
BC000638 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. SNPs on 17q21 locus that are associated with childhood asthma also show a consistent and strong association with transcript levels of ORMDL3, indicating that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma. |
