别 名： carbohydrate sulfotransferase 11; C4ST; C4ST1; C4ST-1; HSA269537
概 述
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Full name: |
carbohydrate sulfotransferase 11 |
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Synonyms: |
C4ST; C4ST1; C4ST-1; HSA269537 |
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Swissprot: |
Q9NPF2 |
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Gene Accession: |
BC013315 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
