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  • 产品名称:CASP1 抗原(重组蛋白)

  • 产品型号:1mg
  • 产品厂商:通蔚生物
  • 产品价格:3580
  • 产品库存:35
  • 产品文档:
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详情介绍:

中文名称: CASP1 抗原(重组蛋白)

英文名称: CASP1 Antigen (Recombinant Protein)

别    名:  caspase 1, apoptosis-related cysteine peptidase; ICE, P45, IL1BC

储    存:  冷冻(-20℃)

相关类别:抗原

概     述

Full length fusion protein

技术规格

Full name:

caspase 1, apoptosis-related cysteine peptidase

Synonyms:

ICE, P45, IL1BC

Swissprot:

P29466

Gene Accession:

BC062327

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.





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