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  • 产品名称：VWA5A抗原（重组蛋白）

  • 产品型号：100ug
  • 产品厂商：通蔚生物
  • 产品价格：800
  • 产品库存：35
  • 产品文档：
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详情介绍：

中文名称： VWA5A抗原（重组蛋白）

英文名称： VWA5A Antigen (Recombinant Protein)

别     名：  BCSC1; BCSC-1; LOH11CR2A

储     存：  冷冻（-20℃）

相关类别： 抗原

概     述：

Fusion protein corresponding to C terminal 250 amino acids of human VWA5A

技术规格

Full name:

von Willebrand factor A domain containing 5A

Synonyms:

BCSC1; BCSC-1; LOH11CR2A

Swissprot:

O00534

Gene Accession:

BC001234

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.





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