储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Full name: |
sphingosine kinase 2 |
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Synonyms: |
SK 2; SK-2; SPK 2; SPK-2 |
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Swissprot: |
Q9NRA0 |
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Gene Accession: |
BC006161 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
