英文名称: UBR7 Antigen (Recombinant Protein)
别 名: ubiquitin protein ligase E3 component n-recognin 7 (putative); C14orf130
相关类别: 抗原
储 存: 冷冻(-20℃)
概 述
| Full name: | ubiquitin protein ligase E3 component n-recognin 7 (putative) | 
| Synonyms: | C14orf130 | 
| Swissprot: | Q8N806 | 
| Gene Accession: | BC015046 | 
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE | 
| Expression system: | Escherichia coli | 
| Tags: | His tag C-Terminus, GST tag N-Terminus | 
| Background: | Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Ubr7 (ubiquitin protein ligase E3 component n-recognin 7), also known as C14orf130 or N-recognin-7, is a 425 amino acid protein that contains one UBR-type zinc finger and one PHD zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr7 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation. | 

