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  • 产品名称：SRGAP3 抗原（重组蛋白）

  • 产品型号：100ug
  • 产品厂商：通蔚生物
  • 产品价格：800
  • 产品库存：35
  • 产品文档：
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简单介绍：
SRGAP3 抗原（重组蛋白）以诚信为本，努力打造上等的品牌，为您提供全方位的售中、售后服务，具有上等的技术团队和上等的产品引入国内市场，满足国内广大客户的需求。
详情介绍：

中文名称： SRGAP3 抗原（重组蛋白）


英文名称： SRGAP3 Antigen (Recombinant Protein)

别    名：   SLIT-ROBO Rho GTPase activating protein 3; WRP; MEGAP; SRGAP2; ARHGAP14

储     存：  冷冻（-20℃）

相关类别： 抗原

概     述

Fusion protein corresponding to N terminal 250 amino acids of human SRGAP3

技术规格

Full name:

SLIT-ROBO Rho GTPase activating protein 3

Synonyms:

WRP; MEGAP; SRGAP2; ARHGAP14

Swissprot:

O43295

Gene Accession:

BC039300

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.








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