中文名称： 兔抗RRP8多克隆抗体
英文名称： Anti-RRP8 rabbit polyclonal antibody
别 名： ribosomal RNA processing 8; NML; KIAA0409
相关类别： 一抗
储 存： 冷冻（-20℃）
宿 主： Rabbit
抗 原： RRP8
反应种属： Human, Mouse, Rat
标 记 物： Unconjugate
克隆类型： rabbit polyclonal
技术规格
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Background: |
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
RRP8 |
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Immunogen: |
Fusion protein of human RRP8 |
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Full name: |
ribosomal RNA processing 8 |
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Synonyms: |
NML; KIAA0409 |
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SwissProt: |
O43159 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human esophagus cancer and Human breast cancer |
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IHC Recommend dilution: |
50-300 |
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WB Predicted band size: |
51 kDa |
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WB Positive control: |
Human cerebella tissue, K562 cell lysates |
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WB Recommended dilution: |
500-2000 |
