英文名称： Anti-PTTG1 rabbit polyclonal antibody
别 名： EAP1; PTTG; HPTTG; TUTR1
相关类别： 一抗
储 存： 冷冻（-20℃）
宿 主： Rabbit
抗 原： PTTG1
反应种属： Human
标 记 物： Unconjugate
克隆类型： rabbit polyclonal
技术规格
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Background: |
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
PTTG1 |
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Immunogen: |
Synthetic peptide of human PTTG1 |
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Full name: |
pituitary tumor-transforming 1 |
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Synonyms： |
EAP1; PTTG; HPTTG; TUTR1 |
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SwissProt: |
O95997 |
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ELISA Recommended dilution: |
1000-5000 |
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IHC positive control: |
Human colon cancer and Human gastric cancer |
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IHC Recommend dilution: |
25-100 |
